| CAS No.: | 156223-05-1 |
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| Formula: | C19h22cl2n2o2 |
| EINECS: | / |
| Type: | Pharmaceutical Intermediates |
| Appearance: | Powder |
| Quality: | Pharmaceutical |
| Samples: |
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| Customization: |
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| Product name | Gts-21 | CAS No. | 156223-05-1 |
| Appearance |
White powder
|
Specification | 99% |
| Origin | China | Brand | Shaanxi Laon |
GTS-21 dihydrochloride is a selective α7 nicotinic acetylcholine receptor agonist, has recently been established as a promising treatment for inflammation. Target: nAChRin vitro: GTS-21 is one of the most potent α7nAChR agonists, has been reported to attenuate pro-inflammatory cytokine production, improve outcomes in sepsis models, pancreatitis, and ischemia-reperfusion injury, and inhibit the production of endotoxin-induced TNF in lung tissue. In addition, recent studies have demonstrated that GTS-21 inhibits the activities of endothelial cells and monocyte macrophages, as well as the secretion of pro-inflammatory cytokines in peripheral blood samples, by regulating the JAK2-STAT3 pathway. [1] in vivo: In septic animals, GTS-21 significantly ameliorated GI motility, lowered systemic and colonic levels of IL-6, decreased colonic permeability, and decreased the number of positive cultures obtained from blood and mesenteric lymph nodes. Splenectomy prevented animals from developing sepsis-induced ileus. Chrna7 mice displayed a more severe septic phenotype, whereas GTS-21 remarkably was also beneficial in these animals.
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Q&A
Q1: How to confirm the Product Quality before placing orders?
A: By sending you our available samples.
Or if you have special requirement on the goods, we can prepare samples according to your requirement for your confirmation.
Q2: Can you supply free samples?
A: Yes, we can provide some free sample, but the shipping cost should be on the customers' account. You can either pay the shipping cost or arrange a courier to collect the samples.
Q3: What's the MOQ?
A: For the high value product, our MOQ starts from 1g and generally starts from 10g.
For other low value product, our MOQ starts from 100g and 1kg.
Q4: How to place order and make payment?
A: You can send our your Purchase order(if your company has), or just send a simple confirmation by email or by TradeManager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.
Q5: How do you treat quality complaint?
A: All our products are strictly tested by our QC, and confirmed by QA; unqualified material will not be released to customer.
In case any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.
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